Smooth. Bright. Radiant.
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SkinCeuticals
Skinceuticals P-TIOX Anti-Wrinkle Serum
Skinceuticals P-TIOX Anti-Wrinkle Serum
Inspired by the results of wrinkle-relaxing injections, P-TIOX helps visibly reduce expression lines, improve texture, and deliver a luminous, glass-skin glow, no needles required.
Benefits at a glance:
- Peptide-powered serum inspired by the effects of wrinkle-relaxing injections
- Smooths wrinkles without needles or downtime
- Improves skin texture and enhances radiance
- Formulated with peptides, 5% PHA, 5% niacinamide, and laminaria extract
- Delivers visibly smoother, glowing skin in just 1 week
- Helps reveal a brighter, glass-skin complexion
Regular price
$127.50 USD
Regular price
$150.00 USD
Sale price
$127.50 USD
Unit price
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per
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How to Use
How to Use
Shipping & Returns
Shipping & Returns
We offer standard shipping on all orders, with delivery estimated between 5–7 business days. You’ll receive a tracking link as soon as your order ships.
We accept returns on unopened items within 14 days of delivery. To initiate a return, please contact our support team with your order details.
Please note: For health and safety reasons, we cannot accept returns on opened or used products.

Key Ingredients
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Acetyl Hexapeptide
A powerful, plant-derived antioxidant that helps neutralize the environmental free radicals that can contribute to premature signs of aging
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PHA
A gentle exfoliating ingredient that helps to improve skin texture, promote cell turnover, and enhance overall skin radiance.
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Niacinamide
Provides antioxidant benefits such as protection from environmental aggressors and enhancing barrier function, keeping skin balanced and healthy.
View All Ingredients
Aqua / Water / Eau / Niacinamide / Gluconolactone / Butylene Glycol / Peg/Ppg/Polybutylene Glycol-8/5/3 Glycerin / Alcohol Denat. / Pentylene Glycol / Methyl Gluceth-20 / Glycerin / Potassium Hydroxide / Hydroxyethylcellulose / Salicylic Acid / Chlorphenesin / Phytic Acid / Adenosine / Sodium Benzoate / Laminaria Digitata Extract / Dipeptide Diaminobutyroyl Benzylamide Diacetate / Acetyl Hexapeptide-8
Please be aware that ingredient lists for the products of our brand are updated regularly. Please refer to the ingredient list on your product package for the most up-to-date list of ingredients to ensure it is suitable for your personal use.
Want to know more about Skinceuticals P-TIOX Anti-Wrinkle Serum?
Frequently Asked Questions
How does an anti-wrinkle serum work?
P-TIOX features a powerful peptide complex inspired by wrinkle-relaxing injectables to visibly soften expression lines and help prevent the formation of new wrinkles.
Do neuro-peptide serums reduce face wrinkles?
P-TIOX is a peptide-powered anti-wrinkle serum formulated to visibly reduce the appearance of facial wrinkles and expression lines. Its advanced peptide complex, combined with polyhydroxy acid (PHA), niacinamide, and laminaria extract, helps improve skin texture, promote cell turnover, and reveal smoother, more radiant skin.
What age should you start using P-TIOX anti-wrinkle serum?
P-TIOX can be incorporated into your skincare routine as early as your 20s to help prevent the visible formation of future wrinkles while softening the appearance of existing expression lines.
Is it better to use anti-wrinkle serums at night or day?
P-TIOX anti-wrinkle serum should be used twice daily. Apply the peptide serum to a dry face morning and night.
Can I use P-TIOX with Retinol?
Yes, P-TIOX pairs well with retinol. Its advanced peptide complex works alongside retinol to visibly reduce the appearance of fine lines and wrinkles while supporting smoother, more youthful-looking skin.
Can I pair P-TIOX with injectables?
Yes, pair P-TIOX with neurotoxin injectables to reduce 5 types of wrinkles and improve skin’s radiance in just one month post injection.*
*Wrinkles in non-injected areas vs. control